| Identification | Back Directory | [Name]
L-Threonine, L-asparaginyl-L-alanyl-L-valyl-L-prolyl-L-asparaginyl-L-leucyl-L-arginylglycyl-L-α-aspartyl-L-leucyl-L-glutaminyl-L-valyl-L-leucyl-L-alanyl-L-glutaminyl-L-lysyl-L-valyl-L-alanyl-L-arginyl- | [CAS]
932699-03-1 | [Synonyms]
A20FMDV2
L-Threonine, L-asparaginyl-L-alanyl-L-valyl-L-prolyl-L-asparaginyl-L-leucyl-L-arginylglycyl-L-α-aspartyl-L-leucyl-L-glutaminyl-L-valyl-L-leucyl-L-alanyl-L-glutaminyl-L-lysyl-L-valyl-L-alanyl-L-arginyl- | [Molecular Formula]
C93H163N31O28 | [MOL File]
932699-03-1.mol | [Molecular Weight]
2163.52 |
| Chemical Properties | Back Directory | [density ]
1.47±0.1 g/cm3(Predicted) | [form ]
Solid | [color ]
White to off-white | [Sequence]
Asn-Ala-Val-Pro-Asn-Leu-Arg-Gly-Asp-Leu-Gln-Val-Leu-Ala-Gln-Lys-Val-Ala-Arg-Thr |
| Hazard Information | Back Directory | [Uses]
A20FMDV2 is a selective αvβ6 integrin inhibitor (IC50: 3 nM), with an activity 1,000-fold more selective for αvβ6 than for other RGD-directed integrins (αvβ3, αvβ5, and α5β1). A20FMDV2 can be derived from the foot-and-mouth disease virus. A20FMDV2 can be radiolabeled for the PET imaging of αvβ6 integrin-positive tumors[1]. | [References]
[1] Hausner SH, et al. Use of a peptide derived from foot-and-mouth disease virus for the noninvasive imaging of human cancer: generation and evaluation of 4-[18F]fluorobenzoyl A20FMDV2 for in vivo imaging of integrin alphavbeta6 expression with positron emission tomography. Cancer Res. 2007 Aug 15;67(16):7833-40. DOI:10.1158/0008-5472.CAN-07-1026 |
|
| Company Name: |
Fuan Bio
|
| Tel: |
15002819872 |
| Website: |
|
|