| Identification | Back Directory | [Name]
4-Bromo-2-(trifluoromethoxy)benzoic acid methyl ester | [CAS]
933785-18-3 | [Synonyms]
2- trifluoromethoxy-4-bromobenzoate
Methyl 4-bromo-2-(trifluoromethoxy)
Ethyl 4-bromo-2-(trifluoromethoxy)benzoate
4-Bromo-2-(trifluoromethoxy)benzoic acid methyl ester
Benzoic acid, 4-bromo-2-(trifluoromethoxy)-, methyl ester | [EINECS(EC#)]
1533716-785-6 | [Molecular Formula]
C9H6BrF3O3 | [MDL Number]
MFCD12761592 | [MOL File]
933785-18-3.mol | [Molecular Weight]
299.04 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of methyl 4-bromo-2-(trifluoromethoxy)benzoate from methanol and 4-bromo-2-trifluoromethoxybenzoic acid: the compound 4-bromo-2-trifluoromethoxybenzoic acid (30.0 g, 0.11 mol) was suspended in a 4 M methanol-hydrochloric acid solution (500 mL), and the reaction was carried out at reflux overnight. After completion of the reaction, methanol was removed by distillation under reduced pressure. The resulting residue was extracted by partitioning with saturated sodium carbonate solution and ethyl acetate. The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product methyl 4-bromo-2-(trifluoromethoxy)benzoate (24.0 g, 77% yield). | [References]
[1] Patent: US2012/28952, 2012, A1. Location in patent: Page/Page column 19
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 16, p. 5979 - 6002 |
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