| Identification | Back Directory | [Name]
CAY10561 | [CAS]
933786-58-4 | [Synonyms]
CAY10561
CAY-10561,CAY10561
CAY10561 Exclusive
YMUYGRBBEDYUOP-UHFFFAOYSA-N
PYRAZOLYLPYRROLE ERK INHIBITOR | [Molecular Formula]
C22H17Cl2FN4O2 | [MDL Number]
MFCD10567088 | [MOL File]
933786-58-4.mol | [Molecular Weight]
459.3 |
| Chemical Properties | Back Directory | [Boiling point ]
733.2±60.0 °C(Predicted) | [density ]
1.463±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 2.5 mg/ml; DMSO: 1.5 mg/ml; Ethanol: 5 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml | [form ]
A crystalline solid | [pka]
12.89±0.50(Predicted) |
| Hazard Information | Back Directory | [Description]
The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary.1 CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM).2 This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM).2 CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 μM.2 | [Uses]
ERK2-IN-4 (Compound 6o) is an effective and selective ERK2 inhibitor with a Ki of 0.006 μM. ERK2-IN-4 inhibits the ERK signaling pathway and can be used in cancer research[1]. | [IC 50]
ERK2: 0.006 μM (Ki) | [References]
1. Junttila, M.R., Li, S.P., and Westermarck, J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival FASEB J. 22,1-12(2008).
2. Aronov, A.M., Baker, C., Bemis, G.W., et al. Flipped out: Structure-guided of selective pyrazolylpyrrole ERK inhibitors J. Med. Chem. 50,1280-1287(2007). |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|