| Identification | Back Directory | [Name]
LY 294002 | [CAS]
934389-88-5 | [Synonyms]
LY 294002, HYDROCHLORIDE SALT
LY 294002, Hydrochloride Salt, >99%
LY-294,002 hydrochloride, ≥98% (HPLC)
LY-294,002 hydrochloride, 98%, selective inhibitor of PI 3-kinase | [Molecular Formula]
C19H18ClNO3 | [MDL Number]
MFCD01530034 | [MOL File]
934389-88-5.mol | [Molecular Weight]
343.804 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: >5mg/mL | [form ]
solid | [color ]
white to off-white | [biological source]
microbial (Staphylococcus roseus) | [InChI]
1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 | [InChIKey]
CZQHHVNHHHRRDU-UHFFFAOYSA-N | [SMILES]
O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4 |
| Hazard Information | Back Directory | [Uses]
LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590). | [General Description]
LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility. | [Biological Activity]
Specific cell permeable phosphatidylinositol 3-kinase inhibitor. | [in vivo]
LY294002 hydrochloride (10, 25, 50, 75 mg/kg; i.p.; twice weekly; for 4 weeks) significantly reduces mean NPC tumor burden in a dose-dependent manner. LY294002 (10, 25 mg/kg) is less effective in decreasing tumor burden[4].
LY294002 hydrochloride (1.2 mg/kg per day; i.p.; for 14 days) prevents Leptin (60 ug/kg)-induced adverse effects on spermatozoa in Sprague-Dawley rats[5]. | Animal Model: | Athymic nude mice (6-8 weeks) with CNE-2Z xenograft[4] | | Dosage: | 10 mg/kg, 25 mg/kg, 50 mg/kg, and 75 mg/kg | | Administration: | IP; twice weekly, for 4 weeks | | Result: | Mean Nasopharyngeal carcinoma (NPC) tumor burden was remarkably decreased in a dose-dependent manner. |
| [IC 50]
CK2: 0.098 μM (IC50); CK2α2: 3.869 μM (IC50) | [storage]
Room temperature |
|
| Company Name: |
NCE Biomedical Co.,Ltd.
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4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
SPIRO PHARMA
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| Tel: |
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www.spiropharma.com.cn |
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