| Chemical Properties | Back Directory | [Melting point ]
265-267 °C(Solv: benzene (71-43-2)) | [Boiling point ]
968.8±65.0 °C(Predicted) | [density ]
1.71±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | [form ]
A solid | [pka]
6.44±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
Kibdelone C is a member of a family of natural heterocyclic polyketides first isolated from a soil actinomycete, Kibdelosporangium. Kibdelones have been described as having potent and selective cytotoxicity against a panel of human tumor cell lines, and kibdelone C has low nanomolar effectiveness in these assays. Kibdelone C disrupts the actin cytoskeleton without directly binding actin or affecting its polymerization in vitro. | [Uses]
Kibdelone C is the major analogue of a potent antitumor complex isolated from Kibdelosporangium sp.. Structurally, kibdelone C is related to lysolipin and albofungin, however no comparative investigation of this class has been reported. The mode of action and pharmacology of the kibdelones has received little attention. | [Uses]
Kibdelone C is the major analogue of a potent antitumor complex. | [Uses]
Kibdelone C is the major analogue of a potent antitumour complex isolated from Kibdelosporangium sp.. Structurally, kibdelone C is related to lysolipin and albofungin, however no comparative investigation of this class has been reported. The mode of action and pharmacology of the kibdelones has received little attention. | [storage]
Store at -20°C | [References]
[1] RANJALA RATNAYAKE. Kibdelones: Novel Anticancer Polyketides from a Rare Australian Actinomycete[J]. Chemistry - A European Journal, 2007, 13 5: 1610-1619. DOI: 10.1002/chem.200601236
[2] JANJIRA RUJIRAWANICH. Synthesis and Biological Evaluation of Kibdelone C and Its Simplified Derivatives[J]. Journal of the American Chemical Society, 2016, 138 33: 10561-10570. DOI: 10.1021/jacs.6b05484 |
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| Company Name: |
Lynnchem
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| Telephone: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
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