| Identification | Back Directory | [Name]
BLX3887 | [CAS]
934758-70-0 | [Synonyms]
BLX3887
1H-Pyrazole-3-carboxamide, 4,5-dichloro-N-(2-chloro-4-fluorophenyl)- | [Molecular Formula]
C10H5Cl3FN3O | [MOL File]
934758-70-0.mol | [Molecular Weight]
308.52 |
| Chemical Properties | Back Directory | [Boiling point ]
395.4±42.0 °C(Predicted) | [density ]
1.714±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 15 mg/ml; DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml | [form ]
A crystalline solid | [pka]
7.07±0.50(Predicted) |
| Hazard Information | Back Directory | [Description]
BLX3887 is an inhibitor of 15-lipoxygenase type 1 (15-LO-1; IC50 = 32 nM in a cell-free enzyme assay).1 It is selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM), and 12-LO (IC50 = 3,310 nM). BLX3887 inhibits the production of 15-LO metabolites selectively in eosinophils over neutrophils when used at a concentration of 10 µM. It also inhibits endocytosis in, and the migration of, isolated human peripheral blood mononuclear cell-derived dendritic cells in vitro.WARNING This product is not for human or veterinary use. |
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