| Identification | Back Directory | [Name]
N–(4–pentynoyl) mannosamine tetraacylated (Ac4ManNAl) | [CAS]
935658-93-8 | [Synonyms]
ManNAcyne
Ac4ManNAl
peracetylated N-(4-pentynoyl)mannosamine
N-(4-pentynoyl)-mannosamine tetraacylated
1,3,4,6-tetra-O-acetyl-N-4-pentynoylmannosamine
N–(4–pentynoyl) mannosamine tetraacylated (Ac4ManNAl)
2-deoxy-2-[(1-oxo-4-pentyn-1-yl)amino]-1,3,4,6-Tetraacetate-D-Mannopyranose
D-Mannopyranose, 2-deoxy-2-[(1-oxo-4-pentyn-1-yl)amino]-, 1,3,4,6-tetraacetate
2-deoxy-2-[(1-oxo- 4-pentyn-1- yl)amino]- 1,3,4,6- Tetraacetate-D[1]Mannopyranose
2-deoxy-2-[(1-oxo-4- pentyn-1-yl) amino] -2- deoxy-1,3,4,6-tetra-O- acetyl-D-mannopyra- nose
1,3,4,6-TETRA-O-ACETYL-N-4-PENTYNOYLMANNOSAMINE; MANNACYNE; PERACETYLATED N-(4-PENTYNOYL)MANNOSAMINE | [Molecular Formula]
C19H25NO10 | [MDL Number]
MFCD33403175 | [MOL File]
935658-93-8.mol | [Molecular Weight]
427.4 |
| Chemical Properties | Back Directory | [Boiling point ]
570.1±50.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [solubility ]
DMSO, DMF, DCM, THF, Chloroform | [pka]
12.63±0.70(Predicted) | [Appearance]
white powder |
| Hazard Information | Back Directory | [Description]
The tetraacetylated N-(4-pentynoyl)-mannosamine (Ac4ManNAl) is an alkyne-labeled monosaccharide that provides a highly specific tool for studying glycoproteins through metabolic labeling in vivo and subsequent chemoselective ligation.
Ac4ManNAl is cell-permeable unnatural sugar that is intracellularly processed and incorporated instead of its natural monosaccharide counterpart N-acetylmannosamine (ManNAc).
The resulting alkyne-contained glycoprotein can be detected via Cu(I)-catalyzed (CuAAC) click reaction with either fluorescent-labeled azides or biotin-azide. |
|
|