ChemicalBook--->CAS DataBase List--->936111-69-2

936111-69-2

936111-69-2 Structure

936111-69-2 Structure
IdentificationBack Directory
[Name]

5-amino-2-(((6R,7R)-7-((Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-4-(3-(2-aminoethyl)ureido)-1-methyl-1H-pyrazol-2-iumhydrogensulfate
[CAS]

936111-69-2
[Synonyms]

FR264205
FR-264205
FR 264205
5-amino-2-(((6R,7R)-7-((Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-4-(3-(2-aminoethyl)ureido)-1-methyl-1H-pyrazol-2-iumhydrogensulfate
[Molecular Formula]

C23H32N12O12S3
[MOL File]

936111-69-2.mol
[Molecular Weight]

764.768
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS08
[Signal word ]

Danger
[Hazard statements ]

H334-H317
[Precautionary statements ]

P261-P285-P304+P341-P342+P311-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
Hazard InformationBack Directory
[Uses]

Ceftolozane Sulfate is an antibiotic belonging to the class of Cephalosporin (Cephalosporin C Zinc Salt, C258750).
[in vivo]

Ceftolozane (400-800 mg/kg, s.c., every 6 h) sulfate reduces ESBL-producing Enterobacteriaceae in neutropenic mice[6].
Ceftolozane (180 mg/kg, s.c., every 8 h, 48 h) sulfate reduces bacterial load and improves early pulmonary inflammatory response without impairing 48 h post-infection homeostasis in a mice model of Pseudomonas aeruginosa acute pneumonia[7].

Animal Model:Neutropenic murine thigh infection model[6]
Dosage:400, 800 mg/kg
Administration:Subcutaneous injection (s.c.), every 6 h
Result:Reduced ESBL-producing Enterobacteriaceae.
Showed that ceftolozane with tazobactam at a 2:1 ratio were significantly different than animals treated with ceftolozane alone.
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