| Identification | Back Directory | [Name]
1H-Indole-2-propanoic acid, 3-[(1,1-diMethylethyl)thio]-1-[[4-(6-Methoxy-3-pyridinyl)phenyl]Methyl]-,-diMethyl-5-(2-pyridinylMethoxy)- | [CAS]
936349-47-2 | [Synonyms]
UNII-B1Z78DJ75Y
AM-103 Free Acid
DGCSBHYGDCRAOB-UHFFFAOYSA-N
1H-Indole-2-propanoic acid, 3-[(1,1-diMethylethyl)thio]-1-[[4-(6-Methoxy-3-pyridinyl)phenyl]Methyl]-,-diMethyl-5-(2-pyridinylMethoxy)-
1H-Indole-2-propanoic acid, 3-[(1,1-dimethylethyl)thio]-1-[[4-(6-methoxy-3-pyridinyl)phenyl]methyl]-α,α-dimethyl-5-(2-pyridinylmethoxy)- | [Molecular Formula]
C36H39N3O4S | [MDL Number]
MFCD18633240 | [MOL File]
936349-47-2.mol | [Molecular Weight]
609.778 |
| Hazard Information | Back Directory | [Uses]
AM103 (free acid) is a selective FLAP inhibitor that can block the first step of the LT pathway, which is 5-LO activation. AM103 (free acid) can inhibit the production of LTB4 and cysteinyl leukotrienes (CysLT). AM103 (free acid) has anti-inflammatory activity in a mouse model of chronic lung inflammation and can extend the survival time of mice injected with platelet-activating factor. AM103 (free acid) can be used for research on respiratory diseases such as asthma[1]. | [References]
[1] Lorrain D S, et al. Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2, 2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation[J]. Journal of Pharmacology and Experimental Therapeutics, 2009, 331(3): 1042-1050. |
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