| Identification | Back Directory | [Name]
Iodo-PEG3-Azide | [CAS]
936917-36-1 | [Synonyms]
I-PEG3-N3
Iodo-PEG4-N3
Iodo-PEG3-Azide
1-azido-2-(2-(2-(2-iodoethoxyl)ethoxy)ethoxy)ethane | [Molecular Formula]
C8H16IN3O3 | [MDL Number]
MFCD25969270 | [MOL File]
936917-36-1.mol | [Molecular Weight]
329.14 |
| Hazard Information | Back Directory | [Description]
Iodo-PEG3-Azide is a PEG linker containing iodide and azide moieties. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The iodide is a very good leaving group for nucleophilic substitution reactions. | [Uses]
Iodo-PEG3-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Iodo-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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