| Identification | Back Directory | [Name]
DF 461 | [CAS]
937051-40-6 | [Synonyms]
DF 461
4H,6H-[1,2,4]Triazolo[4,3-a][4,1]benzoxazepine-4-acetic acid, 8-chloro-6-(2-chloro-3-methoxyphenyl)-1-(trifluoromethyl)-, (4R,6S)- | [Molecular Formula]
C20H14Cl2F3N3O4 | [MOL File]
937051-40-6.mol | [Molecular Weight]
488.24 |
| Hazard Information | Back Directory | [Description]
DF-461 is a squalene synthase inhibitor. | [Uses]
DF 461 is a sterol synthase inhibitor with significant inhibitory activity. DF 461 shows high selectivity for the liver and can effectively inhibit cholesterol synthesis in rat liver. DF 461 has shown the effect of lowering plasma lipids in repeated dosing studies in non-rodents[1]. | [References]
[1] Discovery of DF-461, a Potent Squalene Synthase Inhibitor |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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