| Identification | Back Directory | [Name]
QM31 | [CAS]
937735-00-7 | [Synonyms]
QM31
SVT016426
QM31,QM-31
1H-1,4-Diazepine-5-carboxamide, N-(2-amino-2-oxoethyl)-N,1-bis[2-(2,4-dichlorophenyl)ethyl]-4-(3,3-diphenylpropyl)hexahydro-3,7-dioxo- | [Molecular Formula]
C39H38Cl4N4O4 | [MDL Number]
MFCD34469366 | [MOL File]
937735-00-7.mol | [Molecular Weight]
768.56 |
| Chemical Properties | Back Directory | [Boiling point ]
960.8±65.0 °C(Predicted) | [density ]
1.340±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
15.47±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint[1][2]. | [References]
[1] Mondragón L, et al. A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint. Apoptosis. 2009 Feb;14(2):182-90. DOI:10.1007/s10495-008-0310-x
[2] Orzáez M, et al. Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. PLoS One. 2014 Oct 20;9(10):e110979. DOI:10.1371/journal.pone.0110979
[3] Gortat A, et al. Apaf1 inhibition promotes cell recovery from apoptosis. Protein Cell. 2015 Nov;6(11):833-43. DOI:10.1007/s13238-015-0200-2 |
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