| Identification | Back Directory | [Name]
macrocalin B | [CAS]
93781-75-0 | [Synonyms]
Kaur-16-en-15-one, 7,20:14,20-diepoxy-6,7,11-trihydroxy-, (6β,7α,11β,14S,20S)- | [Molecular Formula]
C20H26O6 | [MOL File]
93781-75-0.mol | [Molecular Weight]
362.42 |
| Hazard Information | Back Directory | [Uses]
Macrocalin B is a diterpenoid, which can be isolated from Isodon xerophilus. Macrocalin B inhibits the proliferation of cancer cells K562, HL-60, A549, MKN, CA and HCT with IC50 of 2.81-171 μM. Macrocalin B inhibits the telomerase in K562 with an IC50 in nanomolar level[1]. | [Definition]
ChEBI: A natural product found in Isodon adenolomus. | [References]
[1] Yang Y, et al., Effects of three diterpenoids on tumour cell proliferation and telomerase activity. Nat Prod Res. 2009;23(11):1007-12. DOI:10.1080/14786410802295149 |
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