| Identification | Back Directory | [Name]
somatotropin releasing hormone (1-29)-amide, N-Ac-Tyr(1)-Phe(2)- | [CAS]
93965-89-0 | [Synonyms]
Acetyl-(Tyr1,D-Phe2)-SerMorelin
Acetyl-(D-Phe2)-GRF (1-29) amide (human)
13:PN:WO2009031916 PAGE:7 claimed protein
somatotropin releasing hormone (1-29)-amide, N-Ac-Tyr(1)-Phe(2)-
1-29-Somatoliberin (human pancreatic islet), N-acetyl-2-D-phenylalanine-29-L-argininamide-
Acetyl-(D-Phe2)-GRF (1-29) amide (human) trifluoroacetate salt Ac-Tyr-D-Phe-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2 trifluoroacetate salt | [Molecular Formula]
C157H252N44O43S | [MDL Number]
MFCD00076539 | [MOL File]
93965-89-0.mol | [Molecular Weight]
3476.01 |
| Chemical Properties | Back Directory | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at -20°C | [form ]
Powder | [Water Solubility ]
Soluble to 2 mg/ml in water | [Sequence]
Ac-Tyr-{d-Phe}-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2 |
| Hazard Information | Back Directory | [Description]
VIP receptor antagonist; inhibits [125I]iodo-VIP binding and selectively inhibits VIP- and GRF-induced effects on adenylyl cyclase. | [Uses]
[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human), a growth hormone releasing factor (GRF) analogue, is a vasoactive intestinal peptide (VIP) antagonist[1]. | [References]
[1] Waelbroeck M, et al. Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 as a VIP antagonist. Endocrinology. 1985 Jun;116(6):2643-9. DOI:10.1210/endo-116-6-2643
[2] Dufes C, et al. Effects of the vasoactive intestinal peptide (VIP) and related peptides on glioblastoma cell growth in vitro. J Mol Neurosci. 2003;21(2):91-102. DOI:10.1385/JMN:21:2:91 |
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