| Identification | Back Directory | [Name]
2-[4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl]carbonyl]-1-piperazinyl]-1-(4-morpholinyl)Ethanone | [CAS]
939981-37-0 | [Synonyms]
5R)-4
2-[4-[[(4S
5-dihydro-4
p53 inhibitor (chiral)
p53-MDM2 inhibitor (chiral)
5-bis(4-chlorophenyl)-2-[4-(1
1-dimethylethyl)-2-ethoxyphenyl]-4
p53 and MDM2 proteins-interaction-inhibitor (chiral)
5-dimethyl-1H-imidazol-1-yl]carbonyl]-1-piperazinyl]-1-(4-morpholinyl)-
2-[4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl]carbonyl]-1-piperazinyl]-1-(
p53 and MDM2 proteinsinteractioninhibitor (chiral),p53 and MDM2 proteins interaction inhibitor (chiral),p-53 and MDM2 proteins-interaction-inhibitor (chiral)
2-[4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl]carbonyl]-1-piperazinyl]-1-(4-morpholinyl)Ethanone
2-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl]carbonyl]-1-piperazinyl]-1-(4-morpholinyl)-ethanone
Ethanone, 2-[4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-(1,1-diMethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-diMethyl-1H-iMidazol-1-yl]carbonyl]-1-piperazinyl]-1-(4-Morpholinyl)-
Ethanone, 2-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl]carbonyl]-1-piperazinyl]-1-(4-morpholinyl)-, rel-
P53 INHIBITOR (CHIRAL); ETHANONE; 2-[4-[[(4S;5R)-4;5-BIS(4-CHLOROPHENYL)-2-[4-(1;1-DIMETHYLETHYL)-2-ETHOXYPHENYL]-4;5-DIHYDRO-4;5-DIMETHYL-1H-IMIDAZOL-1-YL]CARBONYL]-1-PIPERAZINYL]-1-(4-MORPHOLINYL)- | [Molecular Formula]
C40H49Cl2N5O4 | [MDL Number]
MFCD14584417 | [MOL File]
939981-37-0.mol | [Molecular Weight]
734.75 |
| Chemical Properties | Back Directory | [Boiling point ]
788.6±70.0 °C(Predicted) | [density ]
1.24 | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 50 mg/mL (68.05 mM); Water: < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
5?+-.0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
p53 and MDM2 proteins-interaction-inhibitor (chiral) (Compound 32) is an inhibitor of the interaction between p53 and MDM2 proteins. | [storage]
Store at -20°C | [References]
[1] Chen R, et al. A Fusion Protein of the p53 Transaction Domain and the p53-Binding Domain of the Oncoprotein MdmX as an Efficient System for High-Throughput Screening of MdmX Inhibitors. Biochemistry. 2017 Jun 27;56(25):3273-3282. DOI:10.1021/acs.biochem.7b00085 |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
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| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
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| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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