| Identification | Back Directory | [Name]
rel-2-[4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl]carbonyl]-1-piperazinyl]-1-(4-morpholinyl)ethanone | [CAS]
939983-14-9 | [Synonyms]
p53 inhibitor (raceMic)
p53 and MDM2 proteins-interaction-inhibitor (raceMic)
2-(4-((4R,5S)-2-(4-(tert-Butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimehyl-4,5-dihydr
2-(4-((4R,5S)-2-(4-(tert-Butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dime hyl-4,5-dihydro-
Ethanone, 2-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-2-[4-(1,1-diMethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-diMethyl-1H-iMidazol-1-yl]carbonyl]-1-piperazinyl]-1-(4-Morpholinyl)-
rel-2-[4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl]carbonyl]-1-piperazinyl]-1-(4-morpholinyl)ethanone | [Molecular Formula]
C40H49Cl2N5O4 | [MDL Number]
MFCD16039218 | [MOL File]
939983-14-9.mol | [Molecular Weight]
734.75 |
| Chemical Properties | Back Directory | [Boiling point ]
788.563±70.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.24 | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
5.502±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
p53 and MDM2 proteins-interaction-inhibitor (racemic) (Compound 2j) is an inhibitor of the interaction between p53 and MDM2 proteins. | [References]
[1] Vu B, et al. Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development. ACS Med Chem Lett. 2013 Apr 2;4(5):466-9. DOI:10.1021/ml4000657 |
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