| Identification | Back Directory | [Name]
2-(METHYLTHIO)PYRIMIDINE-5-BORONIC ACID PINACOL ESTER | [CAS]
940284-18-4 | [Synonyms]
2-(METHYLTHIO)PYRIMIDINE-5-BORONIC ACID PINACOL ESTER
2-(Methylthio)pyrimidinyl-5-boronic acid pinacol ester
2-(Methylthio)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyriMidine
2-(METHYLTHIO)PYRIMIDINE-5-BORONIC ACID PINACOL ESTER ISO 9001：2015 REACH
PyriMidine,2-(Methylthio)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
2-(methylsulfanyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (2-(methylthio)pyrimidin-5-yl)boronate | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C11H17BN2O2S | [MDL Number]
MFCD07781247 | [MOL File]
940284-18-4.mol | [Molecular Weight]
252.14 |
| Questions And Answer | Back Directory | [Synthesis]
At room temperature and under argon atmosphere, 4,4,4',4',5,5,5',5'-octamethyl-2,2'-bis(1,3,2-dioxaborhexacyclopentane) (1.77 g, 6.95 mmol), potassium acetate (1.36 g, 13.90 mmol), and palladium diacetate (104 mg, 0.463 mol) were added to a stirred solution of 5-bromo-2-(methylthio)pyrimidine (950 mg, 4.63 mmol) in DMF (5 mL). The resulting suspension was degassed with argon for 15 min and then heated overnight at 85 °C. The reaction mixture was cooled to room temperature. EtOAc (10 mL) was added to the reaction mixture, and the reaction mixture was washed with brine (15 mL x 3). The organic phase was dried (MgSO4), filtered, and concentrated. 
| [Application]
Studies have reported that 2-methylthiopyrimidine-5-boronic acid pinaester can be used to prepare the following intermediate, which can be used to prepare substituted imidazo[1,2-a]pyridine derivatives. |
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