| Identification | Back Directory | [Name]
SB 743921 | [CAS]
940929-33-9 | [Synonyms]
CS-1972
SB 743921
SB-743921 HCl
SB 743921 USP/EP/BP
SB 743921 hydrochloride
SB743921;SB743921; SB 743921
(R)-N-(3-Aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl)-4-methylb
(R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl)-4-methylbenzamide hydrochloride
SB 743921; (R)-N-(3-AMINOPROPYL)-N-(1-(3-BENZYL-7-CHLORO-4-OXO-4H-CHROMEN-2-YL)-2-METHYLPROPYL)-4-METHYLBENZAMIDE HYDROCHLORIDE
N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methylbenzamide hydrochloride
SB 743921
N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methylbenzamide hydrochloride
N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methylbenzamide hydrochloride SB 743921 | [Molecular Formula]
C31H34Cl2N2O3 | [MDL Number]
MFCD18385010 | [MOL File]
940929-33-9.mol | [Molecular Weight]
553.519 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
H2O: soluble5mg/mL, clear | [form ]
powder | [color ]
white to beige | [Water Solubility ]
H2O: 5mg/mL, clear | [InChIKey]
MLMZVWABFOLFGV-LNLSOMNWSA-N | [SMILES]
C(N(CCCN)[C@@H](C1OC2=CC(Cl)=CC=C2C(=O)C=1CC1=CC=CC=C1)C(C)C)(=O)C1=CC=C(C)C=C1.[H]Cl |&1:6,r| |
| Hazard Information | Back Directory | [Uses]
SB 743921 Hydrochloride is a mitotic kinesin inhibitor, which can be used to treat lung disease in combination with other therapy. | [Biological Activity]
sb743921 is an inhibitor of kinesin spindle protein (ksp) with ki value of 0.1nm [1].as an inhibitor of mitotic kinesin ksp, sb743921 causes cell cycle arrest in mitosis, results in cell death. sb743921 is developed to treat for cancers. sb743921 is a potent and selective inhibitor. in the affinity assays, sb743921 shows ki values of 0.1nm and 0.12nm for human ksp and mouse ksp, respectively. it has no affinity with other kinesins. in the cellular assay, sb743921 exerts anti-proliferation efficacy in skov3, colo205, mv522 and mx1 with ic50 values of 0.02nm, 0.07nm, 1.7nm and 0.06nm. moreover, sb743921 is shown to have activity against human tumor xenografts colo205, mcf-7, sk-mes, h69, ovcar-3, ht-29, mda-mb-231 and a2780. sb743921 is also effective against p388 lymphocytic leukemia xenografts in mice [1]. | [in vivo]
SB-743921 has good oral bioavailability and pharmacokinetics and induces complete tumor regression in nude mice bearing lung cancer patient xenografts[3]. | [IC 50]
Eg5: 0.1 nM (Ki) | [References]
[1] jackson j r, gilmartin a, dhanak d, et al. a second generation ksp inhibitor, sb-743921, is a highly potent and active therapeutic in preclinical models of cancer. proceedings of the american association for cancer research, 2006, 2006(2): b11. |
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| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Telephone: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15748/0_EN.htm |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
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