| Identification | Back Directory | [Name]
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea | [CAS]
941987-60-6 | [Synonyms]
H-151
H 151 NEW
STING inhibitor
STING antagonist
N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
H151;H-151;H-151;H-151;STING ANTAGONIST
Urea, N-(4-ethylphenyl)-N'-1H-indol-3-yl- | [Molecular Formula]
C17H17N3O | [MDL Number]
MFCD08026581 | [MOL File]
941987-60-6.mol | [Molecular Weight]
279.34 |
| Chemical Properties | Back Directory | [Boiling point ]
399.9±25.0 °C(Predicted) | [density ]
1.298±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Soluble in DMSO (25 mg/ml) | [form ]
solid | [pka]
14.96±0.70(Predicted) | [color ]
Off-white | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | [InChI]
InChI=1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21) | [InChIKey]
UJZDIKVQFMCLBE-UHFFFAOYSA-N | [SMILES]
N(C1=CC=C(CC)C=C1)C(NC1C2=C(NC=1)C=CC=C2)=O |
| Hazard Information | Back Directory | [Description]
H-151 (941987-60-6) is an inhibitor of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduced systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice. | [Uses]
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea (cas# 941987-60-6) is a useful research chemical. It is used in biological studies in the enhancement of transgene expression by beta-catenin inhibitor iCRT14. | [in vivo]
H-151 (750 nmol per mouse; a single i.p.) markedly reduces systemic cytokine responses in CMA-treated mice[1].
H-151 (750 nmol per mouse; i.p. daily for 7 d) exhibits notable efficacy in Trex1 / mice that expressed a bioluminescent IFNβ reporter[1].
H-151 (750 nmol per mouse; i.p.) reaches effective systemic levels, displays a short half-life in the serum and forms an adduct to mmSTING in wild-type mice[1]. | [storage]
Store at +4°C | [References]
1) Haag et al. (2018), Targeting STING with covalent small-molecule inhibitors; Nature 559 269
2) Lee et al. (2019), STING restricts oHSV Replication and Spread in Resistant MPNSYs but Is Dispensable for Basal IFN-Stimulated Gene Upregulation; Mol. Ther. Oncolytics 15 91 [FOCUS Citation] |
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| Company Name: |
Twochem Co.Ltd.
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| Telephone: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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