ChemicalBook--->CAS DataBase List--->942195-86-0

942195-86-0

942195-86-0 Structure

942195-86-0 Structure
IdentificationBack Directory
[Name]

7-hydroxy-N,N,2-triMethyl-3-tosyl-3H-benzo[d]iMidazole-5-carboxaMide
[CAS]

942195-86-0
[Synonyms]

Tegoprazan Impurity 19
7-hydroxy-N,N,2-triMethyl-3-tosyl-3H-benzo[d]iMidazole-5-carboxaMide
4-hydroxy-N,N,2-trimethyl-1-tosyl-1H-benzo[d]imidazole-6-carboxamide
4-hydroxy-N N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-1H-benzimidazole-6-carboxamide
1H-Benzimidazole-6-carboxamide, 4-hydroxy-N,N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-
[Molecular Formula]

C18H19N3O4S
[MDL Number]

MFCD20260231
[MOL File]

942195-86-0.mol
[Molecular Weight]

373.43
Questions And AnswerBack Directory
[Synthesis]

Starting with 4-benzyloxycarbonyl-N,N,2-trimethyl-1H-benzo[D]imidazol-6-carboxamide, 7-hydroxy-N,N,2-triMethyl-3-tosyl-3H-benzo[d]iMidazole-5-carboxaMide was prepared via N-protection with 4-methylbenzenesulfonyl chloride and hydrogenation reduction. The synthetic reaction formula is shown in the figure below:

7-hydroxy-N,N,2-triMethyl-3-tosyl-3H-benzo[d]iMidazole-5-carboxaMide

Chemical PropertiesBack Directory
[Boiling point ]

654.0±65.0 °C(Predicted)
[density ]

1.36±0.1 g/cm3(Predicted)
[pka]

7.07±0.40(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]

Health Hazard (GHS08)Flame (GHS02)
GHS08,GHS02
[Signal word ]

Danger
[Hazard statements ]

H304-H226
[Precautionary statements ]

P501-P240-P210-P233-P243-P241-P242-P280-P370+P378-P331-P303+P361+P353-P301+P310-P403+P235-P405
Hazard InformationBack Directory
[Uses]

7-hydroxy-N,N,2-triMethyl-3-tosyl-3H-benzo[d]iMidazole-5-carboxaMide is mainly used in organic synthesis or pharmaceutical backbone materials. It can be used in the synthesis of benzimidazole derivatives as selective acid pump inhibitors for the treatment of conditions with antagonistic activity mediated by the acid pump, such as gastrointestinal disorders, gastro-oesophageal disorders, gastro-oesophageal reflux disease (GERD), laryngo-pharyngeal reflux disease, peptic ulcers, gastric ulcers, duodenal ulcers, and others.
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