| Identification | Back Directory | [Name]
P11 | [CAS]
942285-55-4 | [Synonyms]
3INP11
3-IN-P11
3 IN P11
PAFAH inhibitor P11
KUBDPRSHRVANQQ-NSOVKSMOSA-N
(2S,6S)-6-(4-tert-butylphenyl)-2-(4-methylphenyl)-1-(4-methylphenyl)sulfonyl-3,6-dihydro-2H-pyridine-5-carboxylic acid | [Molecular Formula]
C30H33NO4S | [MDL Number]
MFCD26792576 | [MOL File]
942285-55-4.mol | [Molecular Weight]
503.65 |
| Chemical Properties | Back Directory | [Boiling point ]
667.0±65.0 °C(Predicted) | [density ]
1.210±0.06 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml | [form ]
A crystalline solid | [pka]
4.02±0.60(Predicted) | [color ]
Light yellow to light brown |
| Hazard Information | Back Directory | [Description]
PAFAH1b2 is a selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3. It acts by impairing cancer cell survival. | [Uses]
P11 is a selective inhibitor of platelet-activating factor acetylhydrolases (PAFAHs) 1b2 and 1b3 that impairs cancer cell survival. P11 exhibits IC50 values of ~40 and 900 nM for PAFAH1b2 and 1b3, respectively[1]. | [References]
[1] Jae Won Chang, et al. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. ACS Chem Biol. 2015 Apr 17;10(4):925-32. DOI:10.1021/cb500893q |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310; |
| Website: |
https://www.weikeqi-biotech.com/ |
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