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942655-44-9

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942655-44-9 Structure

942655-44-9 Structure
IdentificationBack Directory
[Name]

3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide
[CAS]

942655-44-9
[Synonyms]

JK-P3
3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide
Benzamide, 3,4-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-
JK-P3,Inhibitor,HUVEC,Anti-angiogenesis,FGFR,VEGFR,JK P3,Fibroblast growth factor receptor,JKP3,Anti-cancer,inhibit,Endothelial cells,JK-P-3,Vascular endothelial growth factor receptor
[Molecular Formula]

C18H17N3O3
[MDL Number]

MFCD22666405
[MOL File]

942655-44-9.mol
[Molecular Weight]

323.35
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: soluble5mg/mL (clear solution)
[form ]

powder
[color ]

white to beige
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Precautionary statements ]

P264-P270-P301+P312-P330-P501
[Hazard Codes ]

Xn
[Risk Statements ]

22
[WGK Germany ]

3
[HS Code ]

2933.19.4300
Hazard InformationBack Directory
[Uses]

JK-P3 is a potent and pan VEGFR2 inhibitor, with IC50s of 7.83 μM, 27 μM and 5.18 μM for VEGFR2, FGFR1 and FGFR3, respectively. JK-P3 can inhibit VEGF-A-stimulated VEGFR2 activation and intracellular signalling, also inhibits endothelial monolayer wound closure and angiogenesis, as well as fibroblast growth factor receptor kinase activity in vitro. JK-P3 has anti-angiogenic activity[1].
[IC 50]

VEGFR2: 7.83 μM (IC50); FGFR1: 27 μM (IC50); FGFR3: 5.18 μM (IC50)
[References]

[1] Kankanala J, et al. A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis. Br J Pharmacol. 2012;166(2):737-748. DOI:10.1111/j.1476-5381.2011.01801.x
Spectrum DetailBack Directory
[Spectrum Detail]

3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide(942655-44-9)1HNMR
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