| Identification | Back Directory | [Name]
4-N-(cyclopropylmethyl)-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4-diamine | [CAS]
943057-12-3 | [Synonyms]
ZPL-389
ZPL-3893787
PF-03893787
4-N-(cyclopropylmethyl)-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4-diamine
2,4-Pyrimidinediamine, N4-(cyclopropylmethyl)-6-[(3R)-3-(methylamino)-1-pyrrolidinyl]- | [Molecular Formula]
C13H22N6 | [MOL File]
943057-12-3.mol | [Molecular Weight]
262.35 |
| Hazard Information | Back Directory | [Uses]
PF-3893787 is a novel histamine H4 receptor antagonist binding affinity (Ki=2.4 nM) and is also a functional (Ki=1.56 nM) antagonist. | [References]
[1] Mowbray CE, et al. Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6596-602. DOI:10.1016/j.bmcl.2011.07.125 |
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