944129-00-4

944128-99-8

944129-00-4

Preparation of methyl 6-amino-2-chloropyrimidine-4-carboxylate: Methyl 2-chloro-6-(methylsulfonyl)pyrimidine-4-carboxylate (3.7 g, 14.75 mmol) was dissolved in 1,4-dioxane and a methanol solution of 7 N ammonia was added. The reaction mixture was stirred at room temperature for 3 hours. After completion of the reaction, the mixture was concentrated under reduced pressure and the residue was extracted by partitioning with ethyl acetate and water. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford methyl 6-amino-2-chloropyrimidine-4-carboxylate (2.35 g, 85% yield).1H NMR (DMSO-d6): δ 7.6 (br s, 1H), 7.00 (s, 1H), 3.84 (s, 3H), 3.33 (s, 3H).