| Identification | Back Directory | [Name]
Rhuscholide A | [CAS]
944804-58-4 | [Synonyms]
Rhuscholide A
5-hydroxy-3-propan-2-ylidene-7-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]-1-benzofuran-2-one
2(3H)-Benzofuranone, 5-hydroxy-3-(1-methylethylidene)-7-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]- | [Molecular Formula]
C31H42O3 | [MDL Number]
MFCD20274782 | [MOL File]
944804-58-4.mol | [Molecular Weight]
462.66 |
| Hazard Information | Back Directory | [Uses]
Rhuscholide A is a benzofuran lactone that shows significant anti-HIV-1 activity, with an EC50 of 1.62 μM[1]. | [Definition]
ChEBI: Rhuscholide A is a member of the class of 1-benzofurans that is 1-benzofuran-2(3H)-one substituted by a hydroxy group at position 5, a propan-2-ylidene group at position 3 and a (2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl group at position 7. Isolated from Rhus chinensis, it exhibits anti-HIV activity. It has a role as a metabolite and an anti-HIV-1 agent. It is a member of 1-benzofurans, a gamma-lactone and a member of phenols. | [References]
[1] Gu Q, et, al. A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis. Planta Med. 2007 Mar;73(3):279-82. DOI:10.1055/s-2007-967113 |
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