| Identification | Back Directory | [Name]
2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE | [CAS]
945-43-7 | [Synonyms]
DMPH4
6,7-DIMETHYL-5,6,7,8-TETRAHYDRO-PTERINE MONOHYDROC
6,7-DIMETHYL-5,6,7,8-TETRAHYDROPTERIN HYDROCHLORIDE
6,7-dimethyl-5,6,7,8-tetrahydropterin dihydrochloride
6,7-DIMETHYL-5,6,7,8-TETRAHYDROPTERINE MONOHYDROCHLORIDE
2-amino-6,7-dimethyl-4-hydroxy-5,6,7,8-tetrahydropteridine
2-AMINO-4-HYDROXY-6,7-DIMETHYL-5,6,7,8-TETRAHYDROPTERIDINE
6,7-DiMethyl-5,6,7,8-tetrahydropterine hydrochloride >=95%
2-Amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropteridineHCl
2-Amino-6,7-dimethyl-4-hydroxy-5,6,7,8-tetrahydropteridine, DMPH4
2-Amino-6,7-dimethyl-5,6,7,8-tetrahydro-4-pteridinol hydrochloride
2-amino-6,7-dimethyl-5,6,7,8-tetrahydropteridin-4-ol hydrochloride
2-Amino-6,7-dimethyl-5,6,7,8-tetrahydropteridine-4-ol·hydrochloride
2-Amino-6,7-dimethyl-5,6,7,8-tetrahydropteridin-4(1H)-one hydrochloride
2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE HYDROCHLORIDE
2-AMINO-4-HYDROXY-6,7-DIMETHYL-5,6,7,8-TETRAHYDROPTERIDINE HYDROCHLORIDE
2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE
2-Amino-6,7-dimethyl-4-hydroxy-5,6,7,8-tetrahydropteridine hydrochloride,96%
2-Amino-6,7-dimethyl-4-hydroxy-5,6,7,8-tetrahydropteridine, DMPH4, 2-Amino-6,7-dimethyl-5,6,7,8-tetrahydro-4-pteridinol hydrochloride | [EINECS(EC#)]
213-413-8 | [Molecular Formula]
C8H14ClN5O | [MDL Number]
MFCD00012731 | [MOL File]
945-43-7.mol | [Molecular Weight]
231.68 |
| Chemical Properties | Back Directory | [Melting point ]
244-247 °C (dec.)(lit.)
| [storage temp. ]
-20°C | [solubility ]
PBS (pH 7.2): 1 mg/ml | [form ]
White powder. | [InChI]
1S/C8H13N5O.ClH/c1-3-4(2)11-6-5(10-3)7(14)13-8(9)12-6;/h3-4,10H,1-2H3,(H4,9,11,12,13,14);1H | [InChIKey]
GIHYTRGUZVYCQX-UHFFFAOYSA-N | [SMILES]
Cl[H].CC1Nc2nc(N)nc(O)c2NC1C |
| Hazard Information | Back Directory | [Uses]
6, 7-dimethyl-5,6,7, 8-Tetrahydropterin hydrochloride is a synthetic analogue of tetrahydro-L-bioterin and is used as a cofactor required for the NOS isoforms, phenylalanine, tyrosine and tryptophan hydroxylases, and other enzymes[1][2]. | [Biochem/physiol Actions]
Synthetic reduced pterin cofactor for nitric oxide synthetase, and for phenylalanine, tyrosine, and tryptophan hydroxylases; less active than the natural cofactor, tetrahydrobiopterin (BH4). | [References]
[1] Mayer B, et al. In search of a function for tetrahydrobiopterin in the biosynthesis of nitric oxide. Naunyn Schmiedebergs Arch Pharmacol. 1995 May;351(5):453-63. DOI:10.1007/BF00171035
[2] Suckling CJ, et al. 6-Acetyl-7,7-dimethyl-5,6,7,8-tetrahydropterin is an activator of nitric oxide synthases. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1563-6. DOI:10.1016/j.bmcl.2008.01.079 |
| Spectrum Detail | Back Directory | [Spectrum Detail]
2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE(945-43-7)MS
2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE(945-43-7)IR1
2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE(945-43-7)IR2
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