| Identification | Back Directory | [Name]
2,4(1H,3H)-Pyrimidinedione, 6-amino-1,3-dimethyl-5-[[2-(2-pyridinyl)-4-quinolinyl]carbonyl]- | [CAS]
945008-17-3 | [Synonyms]
TM6008
6-Amino-1,3-dimethyl-5-[[2-(2-pyridinyl)-4-quinolinyl]carbonyl]-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 6-amino-1,3-dimethyl-5-[[2-(2-pyridinyl)-4-quinolinyl]carbonyl]-
6-amino-1,3-dimethyl-5-[2-(pyridin-2-yl)quinoline-4-carbonyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
6-Amino-1,3-dimethyl-5-[[2-(2-pyridinyl)-4-quinolinyl]carbonyl]-2,4(1H,3H)-pyrimidinedione (In Carboxymethyl Cellulose Solution) | [Molecular Formula]
C21H17N5O3 | [MDL Number]
MFCD06328076 | [MOL File]
945008-17-3.mol | [Molecular Weight]
387.39 |
| Chemical Properties | Back Directory | [Boiling point ]
576.8±60.0 °C(Predicted) | [density ]
1.377±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
1.38±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
6-Amino-1,3-dimethyl-5-[[2-(2-pyridinyl)-4-quinolinyl]carbonyl]-2,4(1H,3H)-pyrimidinedione is a unique compound, which inhibits PHD (Prolyl Hydroxylases) and stabilized HIF (Hypoxia Inducible Factor) activity in vitro. | [in vivo]
TM6008 (p.o.; 50 mg/kg; single dosage) exhibits plasma Tmax, Cmax, and T1/2 values of 3.5 hour, 0.9 μg/mL and 1.5 hour for TM6008 in rat[1].
TM6008 (p.o.; 100 mg/kg; 7 days) protects against hypoxia-induced apoptotic neuronal death and decreases the number of apoptotic cells in Gerbils after a 5-minute transient global cerebral ischemia[1]. | Animal Model: | Gerbils after a 5-minute transient global cerebral ischemia[1] | | Dosage: | 100 mg/kg | | Administration: | p.o.; 100 mg/kg; 7 days | | Result: | Exerted organ protection against ischemia?in vivo. |
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