| Hazard Information | Back Directory | [Uses]
DS-22-inf-021 is a neuraminidase (NA) inhibitor. DS-22-inf-021 has antiviral activity against influenza viruses[1]. | [in vivo]
DS-22-inf-021 (20-100 mg/kg, i.p., twice daily for 5 days and monitored for 14 days. ) increased survival rate in mice infected with IAV and IBV[1].
| Animal Model: | 8-week-old female BALB/c mice, intranasally inoculated with 50 μL of five 50 % mouse lethal doses of IAV and IBV[1]. | | Dosage: | 20, 50 and 100 mg/kg | | Administration: | After 2 h post-infection, i.p. injection | | Result: | Reached 85 % protection at 100 mg/kg dose. For the B/Samara/32/2018 strain, it was observed that 100 % of mice treated with DS-22-inf-021 at 100 mg/kg. |
| [References]
[1] Izmailyan R, et al. Discovery of new antiviral agents through artificial intelligence: In vitro and in vivo results. Antiviral Res. 2024 Feb;222:105818. DOI:10.1016/j.antiviral.2024.105818 |
|
|