| Identification | Back Directory | [Name]
7-Amino-5-fluoroindolin-2-one | [CAS]
945381-62-4 | [Synonyms]
7-AMino-5-fluoro-2-oxyindole
7-Amino-5-fluoroindolin-2-one
7-amino-5-fluoro-1,3-dihydro-indol-2-one
7-aMino-5-fluoro-1,3-dihydro-2H-Indol-2-one
2H-Indol-2-one, 7-amino-5-fluoro-1,3-dihydro- | [Molecular Formula]
C8H7FN2O | [MDL Number]
MFCD13193359 | [MOL File]
945381-62-4.mol | [Molecular Weight]
166.15 |
| Chemical Properties | Back Directory | [Boiling point ]
383.5±42.0 °C(Predicted) | [density ]
1.413±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
12.52±0.20(Predicted) | [Appearance]
Brown to reddish brown Solid |
| Hazard Information | Back Directory | [Synthesis]
Step 2: 5-Fluoro-7-nitro-1,3-dihydroindol-2-one (20a, 4.0 g, 20 mmol) was dissolved in 200 mL of acetic acid and palladium/activated carbon catalyst (1.0 g, 5%) was added with stirring at room temperature. The reaction mixture was stirred continuously under hydrogen atmosphere. The reaction progress was monitored by thin layer chromatography (TLC) and stopped when the feedstock completely disappeared. The reaction mixture was filtered to remove the catalyst and the filtrate was concentrated under reduced pressure to afford the white solid product 7-amino-5-fluoro-1,3-dihydroindol-2-one (20b, 3.2 g, 97.5% yield). | [References]
[1] Patent: US2010/75952, 2010, A1. Location in patent: Page/Page column 56
[2] Patent: EP2157093, 2010, A1. Location in patent: Page/Page column 51 |
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