| Identification | Back Directory | [Name]
[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- | [CAS]
945526-43-2 | [Synonyms]
ISCK03
ISCK 03; ISCK-03
C-KIT INHIBITOR II
Stem-Cell Factor/c-Kit Inhibitor
SteM-Cell Factor/c-Kit Inhibitor, ISCK03
[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide
4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide
Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2 - Calbiochem
Benzenesulfonamide,4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]
[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- | [Molecular Formula]
C19H21N3O2S | [MDL Number]
MFCD12031591 | [MOL File]
945526-43-2.mol | [Molecular Weight]
355.45 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Soluble in ethanol or DMSO | [form ]
solid | [color ]
yellow | [Sensitive ]
Light Sensitive | [Cosmetics Ingredients Functions]
ANTIOXIDANT
SKIN PROTECTING
BLEACHING | [InChI]
1S/C19H21N3O2S/c1-19(2,3)15-4-10-18(11-5-15)25(23,24)21-16-6-8-17(9-7-16)22-13-12-20-14-22/h4-14,21H,1-3H3 | [InChIKey]
XQABBHBFHWHMKF-UHFFFAOYSA-N | [SMILES]
CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)-n3ccnc3 |
| Hazard Information | Back Directory | [Uses]
Inhibits in vitro phosphorylation of c-Kit. Also inhibits SCF (stem cell factor)-induced c-kit phosphorylation in 501mel human melanoma cells | [Biological Activity]
isck03 is an inhibitor of scf-mediated c-kit activation.the signaling downstream of scf/c-kit plays a key role in the development of various mammalian cells, such as mast cells, melanocytes, primordial germ cells, and hematopoietic progenitor cells. | [in vitro]
previous study showed that the pretreatment of 501mel cells with isck03 could dose-dependently inhibit scf-induced c-kit phosphorylation. isck03 could also inhibit the phosphorylation of p44/42 erk mitogen-activated protein kinase that was known to be involved in scf/c-kit downstream signaling. however, isck03 was not able to inhibit hepatocyte growth factor-induced phosphorylation of p44/42 erk proteins [1]. | [in vivo]
to determine the in vivo efficacy, isck03was orally administered to depilated c57bl/6 mice. results showed that the oral administration of isck03 could induce the dose-dependent depigmentation of newly regrown hair, and this was reversed with cessation of isck03 treatment. in addition, the topical application of isck03 could promote the depigmentation of uv-induced hyperpigmented spots on n brownish guinea pig skin. moreover, the fontana–masson staining analyses showed epidermal melanin was diminished in spots treated with isck03 [1]. | [References]
[1] y. j. na, h. s. baek, s. m. ahn, et al. [4-t-butylphenyl]-n-(4-imidazol-1-yl phenyl)sulfonamide (isck03) inhibits scf/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. biochemical pharmacology 74(5), 780-786 (2007). |
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