| Identification | Back Directory | [Name]
(1S, 3R, 4R, 6S, 7S) - 1- ((Bis(4- Methoxyphenyl) (Phenyl) Methoxy) Methyl) - 3- (2- Isobutyramido- | [CAS]
945628-66-0 | [Synonyms]
CET-rG(ibu) Phosphoramidite
N6-Bz-2'-O-4'-G-Locked-Gr-CET-Phosphoramidite
(1S, 3R, 4R, 6S, 7S) - 1- ((Bis(4- Methoxyphenyl) (Phenyl) Methoxy) Methyl)
(1S, 3R, 4R, 6S, 7S) - 1- ((Bis(4- Methoxyphenyl) (Phenyl) Methoxy) Methyl) - 3- (2- Isobutyramido-
(1s,3r,4r,6s,7s)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(2-isobutyramido-6-oxo-1h-purin-9(6h)-yl)-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-7-yl 2-cyanoethyl diisopropylphosphoramidite
Propanamide, N-[9-[2,5-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-2-methyl- | [Molecular Formula]
C46H56N7O9P | [MOL File]
945628-66-0.mol | [Molecular Weight]
881.95 |
| Hazard Information | Back Directory | [Uses]
5'-ODMT cEt G Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt G Phosphoramidite Amidite shows excellent safety and antisense activity[1][2]. | [References]
[1] Vasquez G, et al. Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839. DOI:10.1093/nar/gkab047
[2] Seth PP, et al. Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues. J Org Chem. 2010 Mar 5;75(5):1569-81. DOI:10.1021/jo902560f
[3] Vasquez G, et al., Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839. DOI:10.1093/nar/gkab047 |
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