| Identification | Back Directory | [Name]
3-bromo-1H-indazole-7-carbonitrile | [CAS]
945762-00-5 | [Synonyms]
INOS-IN-14
3-bromo-7-cyano-1H-indazole
3-bromo-1H-indazole-7-carbonitrile
1H-INDAZOLE-7-CARBONITRILE, 3-BROMO- | [Molecular Formula]
C8H4BrN3 | [MDL Number]
MFCD11848409 | [MOL File]
945762-00-5.mol | [Molecular Weight]
222.04 |
| Chemical Properties | Back Directory | [Boiling point ]
425.3±25.0 °C(Predicted) | [density ]
1.85±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
Solid | [pka]
8.69±0.40(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Uses]
nNOS-IN-1(Compound 14) is an inhibitor for nitric oxide synthases (NOS), that exhibits inhibitory activities against neuroal, inducible and endothelial NOS, with IC50s of 2.5, 5.7 and 13 μM, respectively[1]. | [IC 50]
nNOS: 2.5 μM (IC50); iNOS: 5.7 μM (IC50); eNOS: 13 μM (IC50) | [References]
[1] Cottyn B, et al., Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile. Bioorg Med Chem. 2008 Jun 1;16(11):5962-73. DOI:10.1016/j.bmc.2008.04.056 |
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| Company Name: |
NovoChemy Ltd.
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| Tel: |
021-31261262/ 49 (0)17662837245 |
| Website: |
www.novochemy.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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