| Identification | Back Directory | [Name]
AMG 7980 | [CAS]
947192-73-6 | [Synonyms]
AMG 7980
5-(6,7-dimethoxycinnolin-4-yl)-N-isopropyl-3-methylpyridin-2-amine
5-(6,7-dimethoxycinnolin-4-yl)-3-methyl-N-propan-2-ylpyridin-2-amine
2-Pyridinamine, 5-(6,7-dimethoxy-4-cinnolinyl)-3-methyl-N-(1-methylethyl)- | [Molecular Formula]
C19H22N4O2 | [MDL Number]
MFCD27978958 | [MOL File]
947192-73-6.mol | [Molecular Weight]
338.4 |
| Hazard Information | Back Directory | [Description]
AMG-7980 is a highly specific phosphodiesterase 10A (PDE10A) ligand with good uptake in the striatum. | [Uses]
AMG-7980 exhibits high affinity to phosphodiesterase 10A (PDE10A), with a KD of 0.94 nM. AMG-7980 can be used as a tracer of PDE10A, when labeled with radioactive isotope[1]. | [References]
[1] Hu E, et al., Rapid identification of a novel small molecule phosphodiesterase 10A (PDE10A) tracer. J Med Chem. 2012 May 24;55(10):4776-87. DOI:10.1021/jm3002372 |
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