| Identification | Back Directory | [Name]
CALMIDAZOLIUM CHLORIDE | [CAS]
94724-12-6 | [Synonyms]
R 24571
CALMIDAZOLIUM
COMPOUND 48/80
COMPOUND R24571
R 24571 CHLORIDE
CALMIDAZOLIUM CHLORIDE
CALMODULIN INHIBITOR R 24571
COMPOUND 48/80 TRIHYDROCHLORIDE
Poly-p-methoxyphenethylmethylamine
Benzeneethanamine, 4-methoxy-3,5-bis[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-N-methyl-
[1-BIS-P-CHLOROPHENYL) METHYL]-3-[2,4-DICHLORO-BETA-(2,4-DICHLOROBENZYLOXY) PHENYL]-IMIDAZOLIUM CHLORIDE
1-[BIS(4-CHLOROPHENYL)METHYL]-3-[2,4-DICHLORO-BETA-(2,4-DICHLOROBENZYLOXY)PHENETHYL]IMIDAZOLIUM CHLORIDE
1-[BIS(P-CHLOROPHENYL)METHYL]-3-[2,4-DICHLORO-BETA-(2,4 DICHLOROBENZYLOXY) PHENETHYL]-IMIDAZOLIUM CHLORIDE
1-[BIS(P-CHLOROPHENYL)METHYL]-3-[2-(2,4-DICHLORO-BETA-(2,4-DICHLOROBENZYLOXY)PHENETHYL)]IMIDAZOLIUM CHLORIDE
1-[Bis(4-Chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride
1-[BIS-(4-CHLOROPHENYL)METHYL]-3-[2-(2,4-DICHLOROPHENYL)-2-[(2,4-DICHLOROPHENYL)METHOXY]-ETHYL]-1H-IMIDAZOLIUM CHLORIDE | [Molecular Formula]
C32H45N3O3 | [MDL Number]
MFCD00077679 | [MOL File]
94724-12-6.mol | [Molecular Weight]
519.72 |
| Chemical Properties | Back Directory | [Boiling point ]
630.9±50.0 °C(Predicted) | [density ]
1.050±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
H2O: 50 mg/mL | [form ]
solid | [pka]
10.81±0.10(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways[1][2]. | [References]
[1] Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104. DOI:10.1371/journal.pone.0052104
[2] Wang YH, Taché Y, Harris AG, Kreutner W, Daly AF, Wei JY. Desloratadine prevents compound 48/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique. Allergy. 2005;60(1):117-124. DOI:10.1111/j.1398-9995.2004.00641.x
[3] Darzynkiewicz Z, Carter S. Compound 48/80 impairs cytokinesis in murine leukemic cells. J Cell Physiol. 1984;119(1):1-6. DOI:10.1002/jcp.1041190102 |
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