| Identification | Back Directory | [Name]
Carbonic acid, 4-[[(methoxycarbonyl)oxy]phenylmethyl]phenyl methyl ester | [CAS]
948044-25-5 | [Synonyms]
ACA-28
Carbonic acid, 4-[[(methoxycarbonyl)oxy]phenylmethyl]phenyl methyl ester | [Molecular Formula]
C17H16O6 | [MOL File]
948044-25-5.mol | [Molecular Weight]
316.31 |
| Hazard Information | Back Directory | [Uses]
ACA-28 (compound 2a) is a potent ERK MAPK signaling modulator. ACA-28 selectively inhibits cancer cell growth by inducing apoptosis with ERK hyperactivation
ACA-28 inhibits cell growth of melanoma cells (SK-MEL-28) and normal melanocytes (NHEM), with IC50 values of 5.3 and 10.1 μM, respectively[1]. | [References]
[1] Satoh R, et al. Discovery of new benzhydrol biscarbonate esters as potent and selective apoptosis inducers of human melanomas bearing the activated ERK pathway: SAR studies on an ERK MAPK signaling modulator, ACA-28. Bioorg Chem. 2020 Oct;103:104137. DOI:10.1016/j.bioorg.2020.104137 |
|
|