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949575-20-6

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949575-20-6 Structure

949575-20-6 Structure
IdentificationBack Directory
[Name]

L-Glutamic acid, N-[[[(1S)-1-carboxy-5-[[(4-iodophenyl)methyl]amino]pentyl]amino]carbonyl]-
[CAS]

949575-20-6
[Synonyms]

MIP1072
MIP-1072
MIP 1072
Iofolastat
MIP 1072,MIP1072
L-Glutamic acid, N-[[[(1S)-1-carboxy-5-[[(4-iodophenyl)methyl]amino]pentyl]amino]carbonyl]-
[Molecular Formula]

C19H26IN3O7
[MOL File]

949575-20-6.mol
[Molecular Weight]

535.33
Chemical PropertiesBack Directory
[Boiling point ]

767.8±60.0 °C(Predicted)
[density ]

1.602±0.06 g/cm3(Predicted)
[pka]

3.77±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

MIP-1072 is a small molecule specific prostate-specific membrane antigen (PSMA) inhibitor. MIP-1072 inhibits the glutamate carboxypeptidase activity of PSMA with an Ki value of 4.6 nM. MIP-1072 is promising for research of prostate cancer[1].
[References]

[1] Hillier SM, et al. Preclinical evaluation of novel glutamate-urea-lysine analogues that target prostate-specific membrane antigen as molecular imaging pharmaceuticals for prostate cancer. Cancer Res. 2009 Sep 1;69(17):6932-40. DOI:10.1158/0008-5472.CAN-09-1682
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