| Identification | Back Directory | [Name]
AdipoRon . HCl (water soluble) | [CAS]
949745-75-9 | [Synonyms]
Compound 112254
AdipoR agonist 1
AdipoRon . HCl (water soluble)
Benzamide, 4-(1,1-dimethylethyl)-N-[3-[4-[(4-methoxyphenyl)methyl]-1-piperazinyl]-3-oxopropyl]- | [Molecular Formula]
C26H35N3O3 | [MOL File]
949745-75-9.mol | [Molecular Weight]
437.57 |
| Hazard Information | Back Directory | [Uses]
AdipoR agonist 1 (Compound 112254) is an agonist for adiponectin receptor (AdipoR), which activates the transcriptional regulators like peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). AdipoR agonist 1 is utilized in preventive doping research[1]. | [Biological Activity]
Adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 less potent than AdipoRon. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. | [storage]
+4°C | [References]
[1] Dib J, et al., Identification and characterization of in vitro and in vivo generated metabolites of the adiponectin receptor agonists AdipoRon and 112254. J Pharm Biomed Anal. 2016 Jun 5;125:68-76. DOI:10.1016/j.jpba.2016.03.027 |
|
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
|