| Identification | Back Directory | [Name]
1H-Pyrrole-2-methanamine, N-(2,4-dimethoxyphenyl)-1-[5-(4-methyl-1-piperazinyl)-1,3,4-thiadiazol-2-yl]- | [CAS]
950365-31-8 | [Synonyms]
1H-Pyrrole-2-methanamine, N-(2,4-dimethoxyphenyl)-1-[5-(4-methyl-1-piperazinyl)-1,3,4-thiadiazol-2-yl]- | [Molecular Formula]
C20H26N6O2S | [MOL File]
950365-31-8.mol | [Molecular Weight]
414.53 |
| Chemical Properties | Back Directory | [Boiling point ]
590.0±60.0 °C(predicted) | [density ]
1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [solubility ]
Acetonitrile: Sparingly soluble: 0.1-1 mg/ml
DMSO: Sparingly soluble: 0.1-1 mg/ml | [form ]
Solid | [pka]
6.60±0.42(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GPX4 activator 2 (Compound C3) is an activator of GPX4. GPX4 activator 2 exhibits cardioprotective effects and can inhibit cellular ferroptosis (EC50=7.8 μM). GPX4 activator 2 can be used in the research of myocardial injury[1]. | [References]
[1] Liu X, et al. GPX4 allosteric activators inhibit ferroptosis and exert myocardial protection in doxorubicin-induced myocardial injury mouse model. Eur J Med Chem. 2024 Jul 30;277:116721. DOI:10.1016/j.ejmech.2024.116721 |
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