| Hazard Information | Back Directory | [Description]
MAC-0547630 potent and selective inhibitor of UppS. MAC-0547630 has no off-target effects on membrane potential. | [Uses]
MAC-0547630 is a potent inhibitor of undecaprenyl diphosphate synthase (UppS), with IC50s of 0.05 μM and 1.6 μM for UppSBS and UppSBA, respectively. MAC-0547630 is active against B. subtilis in vitro (MIC 0.1 ng/mL)[1]. | [References]
[1] Tomasz L Czarny, et al. A Small-Molecule Screening Platform for the Discovery of Inhibitors of Undecaprenyl Diphosphate Synthase. ACS Infect Dis. 2016 Jul 8;2(7):489-99. DOI:10.1021/acsinfecdis.6b00044 |
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