| Identification | Back Directory | [Name]
4-Amino-2-hydroxy-5-methylpyridine | [CAS]
95306-64-2 | [Synonyms]
Degarelix Impurity 4
Finerenone Impurity A
Finerenone Impurity 28
Finerenone intermediate
4-amino-5-methylpyridone
4-AMino-5-Methylpyridin-2-ol
4-Amino-5-methylpyridine-2-ol
4-amino-5-methylpyridine-2(1H)-on
4-AMino-5-Methylpyridin-2(1H)-one
4-amino-5-methyl-1H-pyridin-2-one
4-amino-5-methylpyridine-2(1H)-one
4-Amino-2-hydroxy-5-methylpyridine
4-AMino-5-Methyl-2-(1H)-pyridinone
4-Amino-5-methyl-2-hydroxypyridine
2(1H)-Pyridinone, 4-amino-5-methyl-
4-amino-5-methyl-1,2-dihydropyridin-2-one
4-AMino-5-Methylpyridin-2Chemicalbook(1H)-one
4-Amino-5-methyl-2(1H)-pyridinone (4-Amino-5-methyl-2-pyridinol) | [EINECS(EC#)]
682-818-3 | [Molecular Formula]
C6H8N2O | [MDL Number]
MFCD12546373 | [MOL File]
95306-64-2.mol | [Molecular Weight]
124.141 |
| Chemical Properties | Back Directory | [Boiling point ]
291.0±33.0℃ (760 Torr) | [density ]
1.137±0.06 g/cm3 (20 ºC 760 Torr) | [vapor pressure ]
0-0Pa at 20-50℃ | [Fp ]
129.8±25.4℃ | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [pka]
11.90±0.10(Predicted) | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C6H8N2O/c1-4-3-8-6(9)2-5(4)7/h2-3H,1H3,(H3,7,8,9) | [InChIKey]
SSQZBQXJYGNUSC-UHFFFAOYSA-N | [SMILES]
C1(=O)NC=C(C)C(N)=C1 | [LogP]
-0.51 at 20℃ and pH6.3 | [CAS DataBase Reference]
95306-64-2 |
| Hazard Information | Back Directory | [Description]
4-AMino-5-Methylpyridin-2-ol belongs to the pyridine derivatives and is significantly alkaline. Its alcoholic hydroxyl group can undergo corresponding nucleophilic substitution reactions under alkaline conditions. It can be used as a material in organic synthesis and medicinal chemistry. The intermediate is used for the modification and production of drug molecules. For example, the compound can prepare selective mineralocorticoid receptor (MR) antagonist finerenone, which is used to lower the risk of severe kidney and heart problems.
| [Chemical Properties]
4-Amino-5-methyl-2-hydroxypyridine is insoluble in water and soluble in strong polar organic solvents. It has an amino group in its structure and therefore exhibits significant basicity. The carbonyl group in the structure can be considered to exist in an enolic form, and its alcoholic hydroxyl group can undergo the corresponding nucleophilic substitution reaction under basic conditions. | [Uses]
4-Amino-5-methylpyridin-2(1H)-one has been used as a reactant for the synthesis of BAY 94-8862, a nonsteroidal antagonist of the mineralocorticoid receptor to be used for the treatment of cardiorenal diseases. | [Synthesis]
2-Chloro-4-amino-5-methylpyridine, dissolved in ethylene glycol, could be a starting material to synthesize 4-AMino-5-Methylpyridin-2-ol. The crude product could be precipitated by adding hydrochloric acid/methanol solution.
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