| Identification | Back Directory | [Name]
Pirarubicin (Hydrochloride) | [CAS]
95343-20-7 | [Synonyms]
CS-1183
Pinorubin
irarubicin
NSC 654509
Terarubicin
THP hydrochloride
THP-adriamycin HCl
(7S,9S)-7-[(2R,4S,5S,6S)-4-amino-6-methyl-5-[(2S)-oxan-2-yl]oxyoxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione | [Molecular Formula]
C32H37NO12.HCl | [MOL File]
95343-20-7.mol | [Molecular Weight]
664.1 |
| Chemical Properties | Back Directory | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO: 20.83 mg/mL (31.37 mM); Water: < 0.1 mg/mL (insoluble) | [form ]
Solid | [color ]
Pink to red |
| Hazard Information | Back Directory | [Uses]
Pirarubicin Hydrochloride is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors. | [in vivo]
在急性心脏毒性大鼠中，与对照组相比，Pirarubicin (18 mg/kg，iv) 显著提高 BNP、CK-MB、CTnT、LDH 和 MDA 的血清水平。在急性心脏毒性模型中，Pirarubicin Hydrochloride 还可以降低心率，降低 R 波电压，延长 QT 间期[4]。 | [IC 50]
Topoisomerase II | [storage]
4°C, protect from light | [References]
[1] Takigawa N, et al. Cytotoxic effect of topoisomerase II inhibitors against adriamycin- and etoposide-resistant small cell lung cancer sublines. Gan To Kagaku Ryoho. 1993 May;20(7):929-35. PMID:8387762
[2] Nagai K, et al. Relationships between the in vitro cytotoxicity and transport characteristics of pirarubicin and doxorubicin in M5076 ovarian sarcoma cells, and comparison with those in Ehrlich ascites carcinoma cells. Cancer Chemother Pharmacol. 2002 Mar;49(3):244-50. Epub 2002 Jan 8. DOI:10.1007/s00280-001-0404-4
[3] Li K, et al. Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of rapamycin signaling pathway in human bladder cancer cells. Biochem Biophys Res Commun. 2015 May 1;460(2):380-5. DOI:10.1016/j.bbrc.2015.03.042
[4] Wang YD, et al. Cardioprotective effects of rutin in rats exposed to pirarubicin toxicity. J Asian Nat Prod Res. 2017 Oct 27:1-13. DOI:10.1080/10286020.2017.1394292 |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
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| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
Cckinase, Inc.
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| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
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