| Identification | Back Directory | [Name]
3-Quinolinecarboxamide, 4-[(2,4-difluorophenyl)amino]-7-ethoxy-6-(4-methyl-1-piperazinyl)- | [CAS]
953798-95-3 | [Synonyms]
AZ683
3-Quinolinecarboxamide, 4-[(2,4-difluorophenyl)amino]-7-ethoxy-6-(4-methyl-1-piperazinyl)- | [Molecular Formula]
C23H25F2N5O2 | [MOL File]
953798-95-3.mol | [Molecular Weight]
441.47 |
| Hazard Information | Back Directory | [Uses]
AZ683 is a potent and selective 3-amido-4-anilinoquinoline CSF1R inhibitor. AZ683 has high affinity for CSF1R (Ki=8 nM; IC50=6 nM). AZ683 has good oral bioavailability. [11C]AZ683 can be used as a positron emission tomography (PET) radiotracer for colony stimulating factor 1 receptor (CSF1R)[1][2]. | [References]
[1] Tanzey SS, et al. Synthesis and Initial In Vivo Evaluation of [11C]AZ683-A Novel PET Radiotracer for Colony Stimulating Factor 1 Receptor (CSF1R). Pharmaceuticals (Basel). 2018 Dec 13;11(4):136. DOI:10.3390/ph11040136
[2] Scott DA, et al. Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4591-6. DOI:10.1016/j.bmcl.2013.06.031 |
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