| Identification | Back Directory | [Name]
5-BROMO-7-FLUORO-2,3-DIHYDRO-1H-INDOLE | [CAS]
954258-03-8 | [Synonyms]
5-bromo-7-fluoroindoline
5-BROMO-7-FLUORO-2,3-DIHYDRO-1H-INDOLE
1H-Indole, 5-bromo-7-fluoro-2,3-dihydro- | [Molecular Formula]
C8H7BrFN | [MDL Number]
MFCD09739495 | [MOL File]
954258-03-8.mol | [Molecular Weight]
216.05 |
| Chemical Properties | Back Directory | [Boiling point ]
267.1±40.0 °C(Predicted) | [density ]
1.600±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
3.03±0.20(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
7-Fluorodihydroindole (4.5 g, 32.8 mmol) was used as a raw material and dissolved in dichloromethane (10 mL). To this solution was added N-bromosuccinimide (5.8 g, 32.8 mmol). The reaction mixture was stirred at room temperature for 2 hours. Subsequently, the mixture was concentrated under vacuum to remove the solvent. The crude product was purified by silica gel column chromatography with an eluent ratio of petroleum ether:ethyl acetate = 20:1 to afford 5-bromo-7-fluorodihydroindole (4.0 g, 56% yield) as a yellow solid.LCMS analysis showed the molecular ion peak M/Z (M+H) as 216. | [References]
[1] Patent: WO2016/86200, 2016, A1. Location in patent: Page/Page column 346
[2] Patent: US2008/221160, 2008, A1. Location in patent: Page/Page column 10 |
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