| Identification | Back Directory | [Name]
(Z)-3-fluoro-2-(4-Methoxybenzyl)allylaMine hydrochloride | [CAS]
955037-42-0 | [Synonyms]
LJP 1586
LJP-1586 HCl
(Z)-3-fluoro-2-(4-Methoxybenzyl)allylaMine hydrochloride
(Z)-3-fluoro-2-[(4-methoxyphenyl)methyl]prop-2-en-1-amine:hydrochloride | [Molecular Formula]
C11H15ClFNO | [MOL File]
955037-42-0.mol | [Molecular Weight]
231.7 |
| Hazard Information | Back Directory | [Uses]
LJP 1586 is an amine-based inhibitor of semicarbazide-sensitive amine oxidase (SSAO) activity. LJP 1586 is an orally active, potent and selective inhibitor of rodent and human SSAO activity, with IC50 values between 4 and 43 nM[1]. | [in vivo]
LJP 1586 (0-10mg/kg, orally) shows complete inhibition of rat lung SSAO, with an ED50 between 0.1 and 1 mg/kg, and a pharmacodynamic half-life of greater than 24 h[1]. | [References]
[1] O'Rourke AM, et al. Anti-inflammatory effects of LJP 1586 [Z-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride], an amine-based inhibitor of semicarbazide-sensitive amine oxidase activity. J Pharmacol Exp Ther. 2008 Feb;324(2):867-75. DOI:10.1124/jpet.107.131672 |
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