| Identification | Back Directory | [Name]
(S)-1-(2-(3-(4-chlorophenyl)-5,9-dimethyl-7-oxo-7H-furo[3,2-g]chromen-6-yl)acetyl)pyrrolidine-2-carboxylic acid | [CAS]
955918-74-8 | [Synonyms]
L-Proline, 1-[2-[3-(4-chlorophenyl)-5,9-dimethyl-7-oxo-7H-furo[3,2-g][1]benzopyran-6-yl]acetyl]-
(S)-1-(2-(3-(4-chlorophenyl)-5,9-dimethyl-7-oxo-7H-furo[3,2-g]chromen-6-yl)acetyl)pyrrolidine-2-carboxylic acid | [Molecular Formula]
C26H22ClNO6 | [MOL File]
955918-74-8.mol | [Molecular Weight]
479.91 |
| Chemical Properties | Back Directory | [Boiling point ]
739.8±60.0 °C(Predicted) | [density ]
1.399±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.42±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Targocil-II (Compound 2) is an ABC transporter inhibitor with a IC50 value of 137 nM. Targocil-II prevents ATP hydrolysis by binding to allosteric sites of the TM domain. Targocil-II has (antibacterial) activity[1]. | [References]
[1] Matano LM, et al. Antibiotic That Inhibits the ATPase Activity of an ATP-Binding Cassette Transporter by Binding to a Remote Extracellular Site. J Am Chem Soc. 2017 Aug 9;139(31):10597-10600. DOI:10.1021/jacs.7b04726 |
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