| Identification | Back Directory | [Name]
1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine hydrochloride | [CAS]
956025-47-1 | [Synonyms]
100671
1-Naphthyl PP1 HCl
Reaxys ID: 15596117
1-NA-PP 1 hydrochloride
1-Naphthyl PP1 (hydrochloride)
4-d]pyriMidin-4-aMine hydrochloride
1-Tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3
1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine hydrochloride
1-TERT-BUTYL-3-(NAPHTHALEN-1-YL)-1H-PYRAZOLO[3;4-D]PYRIMIDIN-4-AMINE HYDROCHLORIDE;1-NA-PP 1 HYDROCHLORIDE | [Molecular Formula]
C19H20ClN5 | [MDL Number]
MFCD28142637 | [MOL File]
956025-47-1.mol | [Molecular Weight]
353.849 |
| Hazard Information | Back Directory | [Uses]
1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases. 1-Naphthyl PP1 hydrochloride inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively[1]. | [References]
[1] Tandon M, et al. New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells. PLoS One. 2013 Sep 23;8(9):e75601. DOI:10.1371/journal.pone.0075601
[2] Bishop AC, et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 2000 Sep 21;407(6802):395-401. DOI:10.1038/35030148 |
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