| Identification | Back Directory | [Name]
(1R,4S,5S,6S)-4-(L-methionylamino)-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide monohydrate | [CAS]
956385-05-0 | [Synonyms]
LY2140023 hydrate
(1R,4S,5S,6S)-4-(L-methionylamino)-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide monohydrate | [EINECS(EC#)]
691-416-7 | [Molecular Formula]
C12H20N2O8S2 | [MOL File]
956385-05-0.mol | [Molecular Weight]
384.426 |
| Hazard Information | Back Directory | [Uses]
Pomaglumetad methionil (LY2140023 hydrate) is an oral methionine prodrug of the potent specific mGlu2/3 receptor agonist LY404039 (HY-50906). Pomaglumetad methionil is well-tolerated and has a distinct safety profile, and can be used for schizophrenia[1][2]. | [IC 50]
mGluR2; mGluR3 | [References]
[1] Lowe S, et al. Effects of a novel mGlu?/? receptor agonist prodrug, LY2140023 monohydrate, on central monoamine turnover as determined in human and rat cerebrospinal fluid. Psychopharmacology (Berl). 2012 Feb;219(4):959-70. DOI:10.1007/s00213-011-2427-9
[2] Y Anne Pak, et al. In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1. Drug Metab Dispos. 2017 Feb;45(2):137-144. DOI:10.1124/dmd.116.071118 |
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