| Identification | Back Directory | [Name]
2'-DEOXYGUANOSINE 5'-TRIPHOSPHATE DILITHIUM SALT | [CAS]
95648-75-2 | [Synonyms]
DGTP-LI2
2'-DEOXYGUANOSINE 5'-TRIPHOSPHATE DILITHIUM SALT
2''-Deoxy-5''-guanosine-(tetrahydrogen triphosphate) dilithium salt
Guanosine 5'-(tetrahydrogen triphosphate), 2'-deoxy-, dilithium salt
(2R,3S,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-2-[[hydroxy-[hydroxy(phosphonooxy)phosphoryl]oxyphosphoryl]oxymethyl]oxolan-3-olate | [EINECS(EC#)]
306-016-7 | [Molecular Formula]
C10H17LiN5O13P3 | [MDL Number]
MFCD00084699 | [MOL File]
95648-75-2.mol | [Molecular Weight]
515.13 |
| Hazard Information | Back Directory | [Uses]
dGTP-15N5 (2'-Deoxyguanosine-5'-triphosphate-15N5) dilithium is 15N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202(1):e00567-19. Published 2019 Dec 6. DOI:10.1128/JB.00567-19 |
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