| Chemical Properties | Back Directory | [Boiling point ]
668.1±55.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
12.20±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
KU-32 is a C-terminal inhibitor of Hsp90 which increases Hsp70 expression, and protects against neuronal glucotoxicity and reverses multiple clinical indices of diabetic peripheral neuropathy. | [Uses]
KU-32 is a novel, novobiocin-based Hsp90 inhibitor that can protect against neuronal cell death. | [in vivo]
Diabetic BKS-db/db mice, a model for type 2 diabetes, administered KU-32 for 10 weeks do not show any significant changes in blood glucose and insulin levels, despite having greater insulin staining/beta cell in the pancreas compared to untreated BKS db/db mice[1]. | [References]
[1] Farmer K, et al. KU-32, a novel drug for diabetic neuropathy, is safe for human islets and improves in vitro insulin secretion and viability. Exp Diabetes Res. 2012;2012:671673. DOI:10.1155/2012/671673
[2] Urban MJ, et al. Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in diabetic mice. ASN Neuro. 2010 Aug 11;2(4):e00040. DOI:10.1042/AN20100015 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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