| Identification | Back Directory | [Name]
2-Propanol, 1-[[[1-[(2-chlorophenyl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl]methyl]methylamino]-3-(4-ethoxyphenoxy)- | [CAS]
956507-49-6 | [Synonyms]
T-5342126
T 5342126,T5342126
2-Propanol, 1-[[[1-[(2-chlorophenyl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl]methyl]methylamino]-3-(4-ethoxyphenoxy)- | [Molecular Formula]
C25H32ClN3O3 | [MOL File]
956507-49-6.mol | [Molecular Weight]
458 |
| Chemical Properties | Back Directory | [Boiling point ]
626.1±55.0 °C(Predicted) | [density ]
1.16±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Methyl Acetate: 10 mg/ml | [form ]
Liquid | [pka]
13.87±0.20(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50=27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s=110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice. | [storage]
-20°C | [References]
[1] Chavez, et al. Development of β-amino alcohol derivatives that inhibit toll-like receptor 4 mediated inflammatory response as potential antiseptics. J. Med. Chem. 54(13), 4659-4669 (2011). |
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